Astronomy Cialis Online for research project
Today, there are two main types of pain receptors: the first are free nerve endings, when irritated, there is a feeling of dull, diffuse pain, and the second are complex pain receptors, when excited, a feeling of acute and localized pain arises. That is, the nature of pain sensations directly depends on which pain receptors perceived the irritating effect. Regarding specific agents that can irritate pain receptors, we can say that these include various biologically active substances (BAS) formed in pathological foci (so-called algogenic substances). These substances include various chemical compounds - these are biogenic amines, products of inflammation and cell decay, and products of local immune reactions. All these substances, completely different in chemical structure, are capable of irritating pain receptors of different localization. Prostaglandins are substances that support the body's inflammatory response.
How common is chronic pain? According to research by the World Health Organization (WHO), every fifth inhabitant of the planet suffers from chronic pain caused by all kinds of pathological conditions associated with diseases of various organs and systems of the body. This means that at least 20% of people suffer from chronic pain of varying severity, intensity and duration. What is pain and how does it arise? The department of the nervous system is responsible for the transmission of pain sensitivity, substances that cause and maintain pain sensations. The very first stage of pain perception is the impact on pain receptors (nociceptors). These pain receptors are located in all internal organs, bones, ligaments, in the skin, on the mucous membranes of various organs in contact with the external environment (for example, on the intestinal mucosa, nose, throat, etc.).
Since these injuries are minimal, the pain impulses are quite weak, and the pain becomes constant, chronic and accompanies a person everywhere and almost around the clock. The pain becomes habitual, but does not disappear anywhere and remains a source of long-term irritating effect. Pain that persists for six or more months in a person leads to significant changes in the human body. There is a violation of the leading mechanisms of regulation of the most important functions of the human body, disorganization of behavior and psyche. The social, family and personal adaptation of this particular individual suffers.
Congenital pathological processes include the following - various anomalies in the location of internal organs (for example, the location of the heart outside the chest), congenital developmental anomalies (for example, congenital intestinal diverticulum, etc.). Thus, a long-term focus of damage leads to permanent and minor damage to the structures of the body, which also constantly creates a painful impulse about damage to these structures of the body, affected by a chronic pathological process.